Final Programme

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Sunday,16 October 2016
     
16:00 – 18:40 OPENING CEREMONY
Moderators:
David Artis, USA
Tadatsugu Taniguchi, Japan
16:00 – 16:15 WELCOME ADDRESS
Welcome address form Cytokines 2016 Chair
David Artis
16:15 – 17:55 AWARD PRESENTATION
16:15 ICIS President’s welcome message and award presentations
Tadasu Taniguchi
16:20 Milstein Young Investigators (presented by E.N. Fish and J. Towne)
Di Yu
Vineet D. Menachery
Si Ming Man
Andreas Bergthaler
16:30 Christina Fleischmann Award (presented by R. Fleischmann)
Michelle D. Tate
16:40 Pestka Graduate Award (presented by R. Pestka)
Rhiannon Werder
Pestka Post Graduate Award
Scott Read
16:50 2016 Milstein Award (presented by T. Taniguchi)
John O'Shea
Carl Nathan
Jan Vilcek
17:00 2016 Milstein Award Lecture
Carl Nathan
17:30 2016 Honorary Life Membership Award (presented by T. Taniguchi)
Howard Young
17:40 – 18:40 KEYNOTE PRESENTATION

Microbial control of tissue immunity
Yasmine Belkaid, NIH, USA
18:45 Welcome Reception & Networking
Monday,17 October 2016
08:30 - 10:30 Immune regulation of inflammation and cancer
Moderators:
Fiona Powrie, United Kingdom
Steven Ziegler, USA
08:30 Why so many ways to die? The Non-canonical Inflammasome Pathway
Vishva Dixit, Genentech, USA

09:00 O001 - Discovery of a novel transcriptional regulator of sustaining tlr-mediated inflammatory responses
Bin Lin, USA

09:15 New aspects of the regulation of inflammatory responses in the gut
Tadatsugu Taniguchi, IIS, Japan

09:45 O002 - Transgene expression of interleukin-37 in il-10ko mice inhibits colon carcinogensis
Philip Bufler, Germany

10:00 Cytokines and Inflammation in Colorectal Cancer
Michael Karin, UCSD, USA

10:30 - 11:00 Coffee break
11:00 - 13:00 The microbiota and regulation of inflammation
With the kind support of an unrestricted educational grant from Amgen
Moderators:
Yasmine Belkaid, USA
Sarah Gaffen, USA

Cytokine regulation of cellular metabolism
Moderators:
Richard Locksley, USA
Wenjun Ouyang, USA

11:00 Regulation of host immunity by helminth-microbiota interactions
Nicola Harris, EPFL, Switzerland

Maternal antibodies regulate neonatal immunity
Meghan Koch, Berkeley, USA

11:30 O003 - Effects of mycobiota dysbiosis during intestinal inflammation
Irina Leonardi, USA

O005 - LKB1 haploinsufficiency in T cells is sufficient to drive the development of Peutz-Jeghers syndrome
Maya Chikako Poffenberger, Canada

11:45 Gut reactions: Immune pathways in the intestine in health and disease
Fiona Powrie, Oxford, UK

Innate licensing of thermogenesis
Ajay Chawla
12:15 O004 - Microbiome-dependent modulation of mucosal immunity at the ocular surface
Anthony J St. Leger, USA

O006 - Complex regulation of TNF expression controlled by the 3’ untranslated region
Philippe Bouillet, Australia

12:30 Gut microbiota in immune activation
Kenya Honda, Tokyo, Japan

T cell metabolism
Erika Pearce, Freiburg, Germany

13:00 - 15:00 Lunch break, posters, visit of the exhibition
13:00 - 14:00 Lunchtime Trainee Career Panel Discussion
Upon registrations
Dr. Dhaval Patel, Head NIBR, Europe at Novartis, Basel Switzerland
Dr. John Foley, Managing Editor, Science Signaling
Dr. Mandy McGeachy, Assistant Professor, University of Pittsburgh (formerly, DNAX/Merck)
Dr. David Finkel, R&D Systems, Marketing Campaign Manager, Bio-Techne
Dr. Laura Wilson, Director of Health, Strategy & Ventures, Kenneth Rainin Foundation
Dr. Jennifer Towne, Senior Scientific Director, Immunology Discovery, Janssen Research & Development LLC
15:00 - 17:00 To the clinic: emerging therapies
Moderators:
Steven Ziegler, USA
Cem Gabay, Switzerland

Interferons: regulators of immunity and inflammation
With the kind support of an unrestricted educational grant from MedImmune (AstraZeneca)
Moderators:
Eleanor Fish, Canada
Amariliz Rivera, USA

15:00 Targeting the Th17 Immune Axis: from Mechanisms to Clinical Testing
Dan Cua, Merck, USA

Transcriptional regulation of IL-10 and pro inflammatory cytokines in T helper cells
Anne O'Garra, Crick, UK

15:30 O007 - Low-dose interleukin-2 treatment modulates CD4+ T cell subsets selectively in patients with systemic lupus erythematosus
Di Yu, Australia

O009 - Interferon-driven metabolic reprogramming of hepatocytes
Andreas Bergthaler, Austria

15:45 Regulation of type-2 inflammation
Steven Ziegler, Benaroya, USA

Antiviral signaling at the maternal-fetal interface
Carolyn Coyne, UPitt, USA

16:15 O008 - Targeting the IL-7R pathway in leukemia with JAK inhibitors and mAbs
Scott Durum, USA

O010 - IFNAR signaling of myeloid cells modulates viral hepatitis but not kupffer cell replenishment
Katharina Borst, Germany

16:30 IL-17 targeted therapies
Dhavalkumar Patel, Novartis, Switzerland

Distinct contributions of Type I and III IFNs to innate antifungal immunity
Amariliz Rivera, Rutgers, USA

17:00 - 19:00 Posters viewing I with presenters
19:30 - 21:30 Evening Trainee Networking Event
For trainee only
Tuesday,18 October 2016
08:30 - 10:30 Innate and adaptive immune mechanisms of host defense
Moderators:
Dana Philpott, Canada
Peter Staehli

08:30 Interferon Receptor inhibitors, and the role of IgE in SLE
Miguel Sanjuan, MedImmune, USA

09:00 O011 - A "rheostat" function for the GP130/STAT3 signaling cascade for gastrointestinal
Matthias Ernst, Australia

09:15 Autophagy in the control of intracellular infection
Dana Philpott, UToronto, Canada

09:45 O012 - IL-17RA signaling in oral epithelium is necessary and sufficient for protection against oropharyngeal candidiasis
Sarah Gaffen, USA

10:00 Role of early T-bet in T cell activation
Christopher Hunter, UPenn, USA

10:30 - 11:00 Coffee break
11:00 - 13:00 Cytokines and metabolic diseases
Moderators:
Erika Pearce, Germany
Jorge A. Henao-Mejia, USA

Innate immunity at barrier surfaces
Moderators:
Christopher Hunter, USA
Greg Barton, USA

11:00 Dissect inflammatory pathways in the mucosal immunity
Wenjun Ouyang, Amgen, USA

Epithelial Cells-Innate Lymphoid Cells-Th Cells Trio-regulation for Gut Homeostasis and Inflammation
Hiroshi Kiyono, Tokyo, Japan

11:30 O013 - IL-17A exacerbates psoriasiform dermatitis in a mouse model of high-fat diet-induced steatohepatitis
Jean-Claude Lecron, France

O015 - An essential role for epithelial cell histone deacetylase 3 in intestinal host defense
Theresa Alenghat, USA

11:45 Cytokine regulation of immunity and inflammation
David Artis, Cornell, USA

Coordinating innate immunity and tissue homeostasis
Greg Barton, The Regents of the University of California, USA

12:15 O014 - Cardiotrophin-like cytokine (CLCF1) participates in lipoprotein complexes
Sarah Pasquin, Université de Montréal, Canada
O016 - Interferon-lambda controls the spread of respiratory viruses from the upper respiratory tract to the lungs and restricts virus transmission in mice
Peter Staeheli, University of Freiburg, Germany

12:30 Cytokines and transcriptional regulators of tissue-resident T cells
Axel Kallies, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

Crosstalk between mycobiota and host immunity during fungal dysbiosis
Iliyan Iliev, Cornell, USA

13:00 - 15:00 Lunch break, visit of the exhibition
13:30 - 15:00 Official poster viewing and presentations
14:00 - 14:45 ICIS-BIOLEGEND BILL PAUL AWARD LECTURE
Moderators:
John O'Shea, USA
Weiping Jiang, USA
14:00 Introduction by
Weiping Jiang, Biomarker Discovery, USA

14:15 New pathways in type 2 immunity
Richard Locksley, UCSF, USA
15:00 - 17:00 The JICR/Mary Ann Liebert, Inc.
Symposium in Honor of Philip I. Marcus

Moderators:
Ganes Sen, USA
Thomas Hamilton, USA

Primary immunodeficiencies: lessons for cytokine and interferon biology
Moderators:
Nancy Reich, USA
John O'Shea, USA

15:00 New insights into IFN immunity against flaviviruses
Michael Diamond, WashU, USA

Toward a genetic theory of childhood infectious diseases
Jean-Laurent Casanova, Rockefeller, USA

15:30 O017 - Negative regulation of innate immune signaling by the RNA sensor, LGP2
Curt Horvath, Northwestern University, Evanston, USA

O020 - The lab environment recapitulates primary human immune responses in mice
Waleed Elsegeiny, Children's Hospital of Pittsburgh, USA

15:45 Inhibition of type I IFN signaling by flaviviruses
Adolfo Garcia-Sastre, Mount Sinai, USA

New precision medicines emerge from gene identification in congenital immune disorders
Michael J. Lenardo, NIH, Bethesda, USA

16:15 O018 - Loss of autophagy drives inflammation via type I interferons
Mohammad Samie, San Francisco, USA

O021 - Familial autoinflammation with neutrophilic dermatosis reveals a novel regulatory mechanism of pyrin activation
Paul J. Baker, University of Melbourne, Australia

16:30 O019 - Interferon-inducible proteins are essential for the activation of the inflammasomes
Si Ming Man, St. Jude Children’s Research Hospital, USA

O022 - STING-dependent cytokine signaling manifests self DNA induced autoinflammatory disease
Jeonghyun Ahn, University of Miami, USA

16:45 Christina Fleischmann Award Presentation
Michelle Tate, Hudson Institute of Medical Research, Australia

The Sidney & Joan Pestka Post-Graduate Award Presentations
Scott Read, Westmead Institute for Medical Research, Australia

17:30 - 19:30 Cytokines 2016 - Networking reception
Upon registrations
Wednesday, 19 October 2016
08:30 - 10:30 Cytokines and orchestration of innate and adaptive immunity
Moderators:
Greg Sonnenberg, USA
Anne O'Garra, United Kingdom

08:30 Human Th cell subsets in immunity, autoimmunity and immunodeficiencies
Federica Sallusto, IRB, Switzerland

09:00 O023 - IL-27 induced by select candida spp. via TLR7/NOD2 signaling and IFN-B production inhibits fungal clearance
Selinda J. Orr, Cardiff University, UK

09:15 Oxysterols as regulators of immunity
Jason Cyster, UCSF, San Francisco, USA

09:45 O024 - Homeostatic stat5 signaling drives accumulation and function of innate lymphocytes
Alejandro Villarino, NIAMS, Bethesda, USA

10:00 Long non-coding RNAs and the homeostasis of innate immune cells
Jorge A. Henao-Mejia, UPenn, Philadelphia, USA

10:30 - 11:00 Coffee break
11:00 - 13:00 Innate lymphoid cells: first responders in immunity and inflammation
Moderators:
Shigeo Koyasu, Japan
Meghan Koch, USA

Transcriptional and epigenetic regulation of cytokine responses
Moderators:
Daniel Mucida, USA
Jennifer Towne, USA

11:00 Immune regulation of intestinal health
Greg Sonnenberg, Weill Cornell, USA

LC3-associated phagocytosis: Two ancient pathways collide in the regulation of cytokines
Douglas Green, St. Jude Children's Research Hospital, USA

11:30 O025 - Innate lymphoid cell function in allergic inflammation: Arginase 1 is a critical metabolic checkpoint controlling type 2 inflammation
Laurel A. Monticelli, Weill Cornell, USA
O027 - Elucidating the epigenetic regulation of CD4+ T cell derived IL-10 during influenza infection
Nicolette Fonseca, University of British Columbia, Vancouver, Canada

11:45 Innate lymphoid cells promote organ homeostasis
Andreas Diefenbach, Mainz, Germany

Cytokine signaling and genomes
John O’Shea, NIH, Bethesda, USA

12:15 O026 - Regulation and function of the type 2 immune module in adipose tissue
Ari Benjamin Molofsky, University Of California, USA

O028 - Immune-restricted epigenetic reader sp140 maintains transcriptional programs required for macrophage identity and intestinal homeostasis
Kate L. Jeffrey, Harvard, USA

12:30 Regulatory mechanisms for ILC2 activation in allergic inflammation
Shigeo Koyasu, RIKEN, Japan

Tissue adaptation: implications for gut immunity and tolerance
Daniel Mucida, Rockefeller, USA

13:00 Closing of the Meeting
John O’Shea, NIH, Bethesda, USA
Kouji Matsushima, The University of Tokyo, Japan